Teitz T, Chang J C, Kan Y W, Yen T S
Howard Hughes Medical Institute, University of California, San Francisco 94143-0724, USA.
J Pathol. 1995 Nov;177(3):309-15. doi: 10.1002/path.1711770314.
The beta-globin locus control region is known to be a powerful erythroid-specific enhancer. In an attempt to produce immortalized erythroid percursor cells, transgenic mice have been generated with the simian virus (SV) 40 T antigen gene under the control of the locus control region. As previously reported, transgenic mice did not develop erythroleukaemia, but rather succumbed to insulinomas and poorly differentiated rhabdomyosarcomas. This paper describes additional mice containing this transgene that developed thymomas of the mixed epithelial/lymphocytic type, in which only the epithelial component expressed the T antigen. Epithelial cell lines have been established from these tumours. This system may be useful in future studies on the pathogenesis of thymomas and the function of thymic epithelial cells.
β-珠蛋白基因座控制区是一种强大的红系特异性增强子。为了产生永生化的红系前体细胞，人们构建了在基因座控制区控制下携带猿猴病毒（SV）40 T抗原基因的转基因小鼠。如先前报道，转基因小鼠并未发生红白血病，而是死于胰岛素瘤和低分化横纹肌肉瘤。本文描述了携带该转基因的其他小鼠，这些小鼠发生了混合上皮/淋巴细胞型胸腺瘤，其中只有上皮成分表达T抗原。已从这些肿瘤中建立了上皮细胞系。该系统可能对未来胸腺瘤发病机制和胸腺上皮细胞功能的研究有用。
