Hou M F, Huang T J, Hsieh J S, Huang Y S, Huang C J, Chan H M, Wang J Y, Chen Y L, Jong S B, Yang C C
Department of Surgery & Nuclear Medicine, Kaohsiung Medical College, Taiwan, Republic of China.
Gaoxiong Yi Xue Ke Xue Za Zhi. 1995 Dec;11(12):660-6.
The monoclonal antibodies CA15-3 were developed against the two antigens 115D8 of the human milk fat globule membrane and DF3 of breast cancer. CA15-3 was assayed radioimmunologically and CEA was analysed using the enzyme immunoassay. Normal control was achieved in 32 healthy women, the mean values for CA15-3 were 11.5 +/- 3.0 u/ml, range from 7.9 to 16.9 u/ml. We compared serum levels of CA15-3 and CEA in 121 patients with histologically proved breast carcinoma. CA15-3 levels above 25 u/ml and CEA levels above 5 ng/ml were considered positive values. 31 of 121 patients studied had elevated CA15-3 levels (sensitivity: 25.6%) and 21 of 121 patients had positive CEA levels (sensitivity 17.4%). 92 of the breast cancer patients (76%) did not have metastatic disease. In this group CA15-3 sensitivity was 7.6%, while CEA sensitivity was 6.5%. Mean values were 15.1 +/- 6.6 u/ml for CA15-3 and 1.78 +/- 2.47 ng/ml for CEA. 29 patients (24%) had metastatic disease. In this group, CA15-3 sensitivity was 82.8% and CEA sensitivity was 51.7% (P < 0.05). Mean values for CA15-3 were 147.5 +/- 175.9 u/ml and 16.9 +/- 24.0 ng/ml of CEA. With regard to the correlation of two tumor markers with clinical course patients had significantly higher levels of CA15-3 than of CEA in metastatic breast cancer. This result suggests CA15-3 to be the more sensitive and more specific of the two for metastatic breast cancer detection and monitoring.
单克隆抗体CA15 - 3是针对人乳脂肪球膜的两种抗原115D8和乳腺癌的DF3研制的。采用放射免疫法检测CA15 - 3，用酶免疫法分析癌胚抗原（CEA）。32名健康女性作为正常对照，CA15 - 3的平均值为11.5±3.0 u/ml，范围为7.9至16.9 u/ml。我们比较了121例经组织学证实的乳腺癌患者的血清CA15 - 3和CEA水平。CA15 - 3水平高于25 u/ml和CEA水平高于5 ng/ml被视为阳性值。在121例研究患者中，31例CA15 - 3水平升高（敏感性：25.6%），21例CEA水平呈阳性（敏感性17.4%）。92例乳腺癌患者（76%）无转移疾病。在该组中，CA15 - 3的敏感性为7.6%，而CEA的敏感性为6.5%。CA15 - 3的平均值为15.1±6.6 u/ml，CEA为1.78±2.47 ng/ml。29例患者（24%）有转移疾病。在该组中，CA15 - 3的敏感性为82.8%，CEA的敏感性为51.7%（P<0.05）。CA15 - 3的平均值为147.5±175.9 u/ml，CEA为16.9±24.0 ng/ml。关于两种肿瘤标志物与临床病程的相关性，转移性乳腺癌患者的CA15 - 3水平显著高于CEA水平。这一结果表明，在转移性乳腺癌的检测和监测中，CA15 - 3在两者中更敏感、更具特异性。
