Yokozaki M, Kodama T, Yokose T, Nishimura M, Yoshida J, Mizokami H, Nagai K
Division of Thoracic Oncology, National Cancer Center Hospital East, Chiba.
Jpn J Clin Oncol. 1996 Feb;26(1):53-7. doi: 10.1093/oxfordjournals.jjco.a023179.
Although lipomas are common benign neoplasms of soft tissue, endobronchial lipoma is rare. We have treated three patients with endobronchial lipoma over the five years. In two of them lesions were located in segmental or subsegmental bronchi and produced no symptoms. There are very few such cases reported in the English medical literature. In the first case, pneumonectomy was performed because of destruction of the lung due to recurrent pneumonia. The second case had no symptoms and the tumor was located at the bifurcation of right B4a and B4b. A right middle lobectomy was performed, because the distal end of the tumor could not be visualized by fiberoptic bronchoscopy. In the third case, which was a case of lung cancer, an endobronchial lipoma was found during fiberoptic bronchoscopy, and was completely removed endoscopically. Due to their benign nature, endobronchial lipomas should be initially treated with endoscopic surgery or endoscopic laser vaporization. Nevertheless, if the tumor is large and dumbbell-shaped on tomography or CT, endoscopic procedures are not appropriate. Furthermore, if destructive pulmonary change due to the tumor is severe, the remaining peripheral lung will not recover after endoscopic procedures, even if they are removed successfully. When the biopsy specimen is too small to allow evaluation of the whole tumor, surgical resection should also be considered for definitive diagnosis.
虽然脂肪瘤是常见的软组织良性肿瘤,但支气管内脂肪瘤却很罕见。在过去五年中,我们治疗了三例支气管内脂肪瘤患者。其中两例病变位于段或亚段支气管,且无任何症状。英文医学文献中报道的此类病例极少。第一例因反复肺炎导致肺部破坏而进行了肺切除术。第二例无症状,肿瘤位于右肺B4a和B4b的分叉处。由于纤维支气管镜无法看到肿瘤远端,因此进行了右中叶切除术。第三例是肺癌患者,在纤维支气管镜检查时发现了支气管内脂肪瘤,并通过内镜将其完全切除。鉴于支气管内脂肪瘤的良性性质,应首先采用内镜手术或内镜激光汽化治疗。然而,如果肿瘤在断层扫描或CT上显示较大且呈哑铃状,则内镜手术并不合适。此外,如果肿瘤导致的肺部破坏性改变严重,即使内镜手术成功切除肿瘤,剩余的外周肺也无法恢复。当活检标本过小无法对整个肿瘤进行评估时,为明确诊断也应考虑手术切除。