Dash B M
Regional Medical Research Centre, Indian Council of Medical Research, Chandrasekharpur, Bhubaneswar, India.
Mov Disord. 1995 Sep;10(5):622-9. doi: 10.1002/mds.870100515.
Tremors reflected in the handwriting in nine right-handed male patients with right-sided cerebellar lesions were studied by reversibly blocking peripheral inputs from the hand. Blocking was achieved by applying a sphygmomanometer cuff over the mid-arm and increasing the pressure up to 200 mm Hg. Evoked potentials from the ulnar nerve and handwriting were monitored in each subject at periodic intervals. Improvement in writing was noticed in 3-5 min in different subjects that coincided with partial reduction of the amplitude of the neurograms. This reduction is consistent with dissociate conduction in a small population of large medullated fibers. On releasing the cuff, the neurograms returned to their normal height within the same time frame of 3-5 min, and the handwriting deteriorated with return of tremor. No change in the handwriting of the volunteers was observed at any stage. The ages of the volunteers ranged from 25 to 48 years and those of the patients from 28 to 56 years. The duration of illness of the patients ranged from 1 to 8 years.
通过可逆性阻断手部外周输入，对9例右侧小脑病变的右利手男性患者笔迹中反映出的震颤进行了研究。阻断是通过在手臂中部套上血压计袖带并将压力增加到200毫米汞柱来实现的。定期监测每个受试者尺神经的诱发电位和笔迹。不同受试者在3 - 5分钟内笔迹有所改善，这与神经图振幅部分降低相一致。这种降低与一小部分大髓鞘纤维的分离传导一致。松开袖带后，神经图在3 - 5分钟的相同时间内恢复到正常高度，随着震颤的恢复笔迹恶化。在任何阶段均未观察到志愿者笔迹有变化。志愿者年龄在25至48岁之间，患者年龄在28至56岁之间。患者病程为1至8年。
