Ciesielski D, Dziewulska-Bokiniec A, Zółtowska A, Roszkiewicz A, Kopacz A, Wojtacki J
Department of Immunopathology, Medical University of Gdańsk, Poland.
Neoplasma. 1995;42(5):235-7.
In this article the results of molecular marker p53 examinations were presented in relation to the following established breast cancer prognostic factors: age, histologic type, histologic grade, lymph node involvement, tumor size as well as estrogen a progesterone receptor status. Twenty one percent of these primary breast cancer specimens exhibited the overexpression of p53 protein. Significant associations were found between p53 overexpression and younger age, high histologic grade and low content of estrogen and progesterone receptors. Identification of p53-positive breast carcinomas potentially represents a clinically useful indicator of breast cancer aggressiveness.
在本文中，呈现了分子标志物p53检测结果与以下已确立的乳腺癌预后因素的关系：年龄、组织学类型、组织学分级、淋巴结受累情况、肿瘤大小以及雌激素和孕激素受体状态。这些原发性乳腺癌标本中有21%表现出p53蛋白过表达。发现p53过表达与较年轻的年龄、高组织学分级以及雌激素和孕激素受体低含量之间存在显著关联。p53阳性乳腺癌的鉴定可能代表了一种临床上有用的乳腺癌侵袭性指标。
