Beno I, Staruchová M, Volkovová K, Bátovský M
Research Institute of Nutrition, Bratislava, Slovakia.
Neoplasma. 1995;42(5):265-9.
Most colon carcinomas are preceded by an adenomatous polyp--adenoma-carcinoma sequence. Active oxygen species (AOS) can play a role in the pathogenesis of this process. Antioxidant enzymes (AE) are the primary defense against the deleterious effect of AOS. Activities of AE in 56 individuals with colorectal adenoma (CA), 29 individuals with colorectal carcinoma (CC) and in 24 control subjects were examined. Biopsy specimens from the non-neoplastic colonic mucosa and from the CA and CC were taken during colonoscopy for histological and enzymological analysis. Activities of following AE were estimated: CuZn-superoxide dismutase (CuZn-SOD), catalase (CAT) and glutathione peroxidase (GPx). It was found that individuals with CA and CC were characterized by: (1) increased activities of CAT and GPx in non-neoplastic mucosa, that persisted in some of the patients even after removal of tumors; (2) increased activities of CuZn-SOD, CAT and PGx in CA and CC tissues. It can be inferred that the accumulation of peroxides in the non-neoplastic colonic mucosa induced higher activities of CAT and GPx. The reasons of high activities of all AE in the tissues of CA and CC and their relation to carcinogenesis are not clear and require further studies.
大多数结肠癌之前都有一个腺瘤性息肉——腺瘤-癌序列。活性氧（AOS）可在这一过程的发病机制中发挥作用。抗氧化酶（AE）是抵御AOS有害作用的主要防线。检测了56例大肠腺瘤（CA）患者、29例结肠癌（CC）患者及24例对照者的AE活性。在结肠镜检查期间，从非肿瘤性结肠黏膜以及CA和CC处采集活检标本，进行组织学和酶学分析。评估了以下AE的活性：铜锌超氧化物歧化酶（CuZn-SOD）、过氧化氢酶（CAT）和谷胱甘肽过氧化物酶（GPx）。结果发现，CA和CC患者的特征为：（1）非肿瘤性黏膜中CAT和GPx活性增加，甚至在部分患者切除肿瘤后仍持续存在；（2）CA和CC组织中CuZn-SOD、CAT和PGx活性增加。可以推断，非肿瘤性结肠黏膜中过氧化物的积累诱导了CAT和GPx活性升高。CA和CC组织中所有AE活性升高的原因及其与致癌作用的关系尚不清楚，需要进一步研究。
