MacLennan A J, Lee N, Walker D W
Department of Neuroscience, University of Florida Brain Institute, University of Florida College of Medicine, Gainesville 32610-0244, USA.
Neurosci Lett. 1995 Sep 8;197(2):105-8. doi: 10.1016/0304-3940(95)11922-j.
We have previously demonstrated that chronic ethanol consumption decreases neurotrophic activity in hippocampal extracts, as assessed by a chick dorsal root ganglia bioassay, but has no effect on hippocampal NGF mRNA or NGF protein levels. We presently report that hippocampal mRNAs encoding neurotrophin-3 and basic fibroblast growth factor are also unaffected. However, in contrast, brain-derived neurotrophic factor mRNA is reliably decreased, thereby suggesting that ethanol-induced damage of the septohippocampal system may at least partially result from an ethanol-induced decrease in hippocampal brain-derived neurotrophic factor expression.
我们之前已经证明，通过鸡背根神经节生物测定法评估，长期摄入乙醇会降低海马提取物中的神经营养活性，但对海马神经生长因子（NGF）mRNA或NGF蛋白水平没有影响。我们目前报告称，编码神经营养因子-3和碱性成纤维细胞生长因子的海马mRNA也未受影响。然而，相比之下，脑源性神经营养因子mRNA确实可靠地减少了，从而表明乙醇诱导的隔海马系统损伤可能至少部分是由乙醇诱导的海马脑源性神经营养因子表达降低所致。
