Fowler J C
Department of Physiology, Texas Tech University Health Sciences Center, Lubbock 79430, USA.
Neurosci Lett. 1995 Sep 8;197(2):97-100. doi: 10.1016/0304-3940(95)11920-r.
Substituting choline for sodium resulted in an extracellularly recorded transient depolarization and increased efflux of glutamate and adenosine from rat hippocampal slices. The depolarization was blocked by a combination of NMDA and non-NMDA antagonists, MK-801 (10 microM) and 6,7-dinitroquinoxaline-2,3-dione (DNQX, 50 microM). Adenosine release was blocked by MK-801 alone. These data suggest that glutamate released as a result of the sodium removal acts at NMDA and non-NMDA glutamate receptors to trigger the depolarization and acts at NMDA receptors to trigger adenosine release.
用胆碱替代钠会导致在细胞外记录到短暂的去极化，并增加大鼠海马切片中谷氨酸和腺苷的外流。这种去极化被NMDA和非NMDA拮抗剂MK-801（10微摩尔）和6,7-二硝基喹喔啉-2,3-二酮（DNQX，50微摩尔）的组合所阻断。腺苷释放仅被MK-801阻断。这些数据表明，由于钠的去除而释放的谷氨酸作用于NMDA和非NMDA谷氨酸受体以触发去极化，并作用于NMDA受体以触发腺苷释放。
