Dunphy C H, Martin A W, Dunphy F R
Department of Pathology, St. Louis University Health Sciences Center, Missouri, USA.
Mod Pathol. 1995 Oct;8(8):803-10.
We report an unusual case of natural killer cell lymphoproliferative disorder of granular lymphocytes associated with a T-cell receptor (TCR)-beta gene rearrangement. The patient developed the disorder 1 month after cessation of fludarabine therapy for a B-cell lymphoproliferative disorder. The B-cell lymphoproliferative disorder was no longer detectable when the natural killer cell lymphoproliferative disorder persisted. Review of the literature reveals only one reported case of natural killer cell lymphoproliferative disorder of granular lymphocytes associated with a TCR-delta gene rearrangement.
我们报告了一例罕见的颗粒淋巴细胞自然杀伤细胞淋巴增殖性疾病，该疾病与T细胞受体（TCR）-β基因重排相关。患者在接受氟达拉滨治疗B细胞淋巴增殖性疾病停药1个月后发生了该疾病。当自然杀伤细胞淋巴增殖性疾病持续存在时，B细胞淋巴增殖性疾病已无法检测到。文献回顾显示，仅有一例报告的颗粒淋巴细胞自然杀伤细胞淋巴增殖性疾病与TCR-δ基因重排相关。
