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[在实验性大鼠模型中诱导针对胸膜肺炎放线杆菌的多价免疫]

[Induction of polyvalent immunity against Actinobacillus pleuropneumoniae in an experimental rat model].

作者信息

Herrera L, Montiel E, Rosales M E, Bárcenas G, Lara A V, Montaraz J A

机构信息

Facultad de Estudios Superiores-Cuautitlán, UNAM, Laboratorio de Inmunología, Cuautitlán Izcalli, Estado de México.

出版信息

Rev Latinoam Microbiol. 1995 Apr-Jun;37(2):147-52.

PMID:8552874
Abstract

Using an experimental model of passive immunity in the rat, the immunizing effect of live cells of Actinobacillus pleuropneumoniae serotypes 1, 3, 5, 7, 9 and 12 was tested against a challenge with serotype 1. It was observed that serotypes 5, 7 and 9 induced polyvalent immunity. Additionally, agglutinating antibodies to the homologous and heterologous serotype were titrated in the sera of immunized mothers; the results indicated that groups immunized with serotypes 5, 7 and 9 had higher titers against serotype 1.

摘要

利用大鼠被动免疫的实验模型,测试了胸膜肺炎放线杆菌1、3、5、7、9和12型活细胞针对1型菌株攻击的免疫效果。观察到5、7和9型诱导了多价免疫。此外,还对免疫母鼠血清中的同源和异源血清型凝集抗体进行了滴定;结果表明,用5、7和9型免疫的组针对1型血清型的滴度更高。

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