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重组人脱氧核糖核酸酶用于治疗因分泌物潴留所致的肺叶肺不张

Recombinant human DNase in management of lobar atelectasis due to retained secretions.

作者信息

Touleimat B A, Conoscenti C S, Fine J M

机构信息

Section of Pulmonary and Critical Care Medicine, Norwalk Hospital, Connecticut 06856, USA.

出版信息

Thorax. 1995 Dec;50(12):1319-21; discussion 1323. doi: 10.1136/thx.50.12.1319.

DOI:10.1136/thx.50.12.1319
PMID:8553310
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1021360/
Abstract

Recombinant human deoxyribonuclease (rhDNase) is an agent which reduces the viscoelasticity of purulent sputum. Two cases are reported in which rhDNase was utilised for the management of lobar atelectasis due to retained purulent secretions.

摘要

重组人脱氧核糖核酸酶（rhDNase）是一种可降低脓性痰液粘弹性的药物。本文报告了两例使用rhDNase治疗因脓性分泌物潴留导致的肺叶肺不张的病例。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2da8/1021360/aaeb2961a728/thorax00317-0104-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2da8/1021360/396118d8ea11/thorax00317-0104-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2da8/1021360/aaeb2961a728/thorax00317-0104-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2da8/1021360/396118d8ea11/thorax00317-0104-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2da8/1021360/aaeb2961a728/thorax00317-0104-b.jpg

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本文引用的文献

1
Liquefaction of viscous purulent exudates by deoxyribonuclease.脱氧核糖核酸酶对粘性脓性渗出物的液化作用。
Lancet. 1950 Dec 9;2(6641):739-42. doi: 10.1016/s0140-6736(50)91676-x.
2
Lobar atelectasis in cystic fibrosis and treatment with recombinant human DNase I.囊性纤维化中的肺叶肺不张及重组人脱氧核糖核酸酶I治疗
Respir Med. 1994 Apr;88(4):313-5. doi: 10.1016/0954-6111(94)90063-9.
3
Effect of aerosolized recombinant human DNase on exacerbations of respiratory symptoms and on pulmonary function in patients with cystic fibrosis. The Pulmozyme Study Group.
雾化重组人脱氧核糖核酸酶对囊性纤维化患者呼吸道症状加重及肺功能的影响。Pulmozyme研究组。
N Engl J Med. 1994 Sep 8;331(10):637-42. doi: 10.1056/NEJM199409083311003.
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Recombinant human DNase I reduces the viscosity of cystic fibrosis sputum.重组人脱氧核糖核酸酶I降低囊性纤维化痰液的黏稠度。
Proc Natl Acad Sci U S A. 1990 Dec;87(23):9188-92. doi: 10.1073/pnas.87.23.9188.
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A preliminary study of aerosolized recombinant human deoxyribonuclease I in the treatment of cystic fibrosis.
N Engl J Med. 1992 Mar 19;326(12):812-5. doi: 10.1056/NEJM199203193261207.
8
Acute lobar atelectasis: a prospective comparison of fiberoptic bronchoscopy and respiratory therapy.
Am Rev Respir Dis. 1979 Jun;119(6):971-8. doi: 10.1164/arrd.1979.119.6.971.