Fosse E, Heier H E
Transfusjonskomiteen, Ullevål sykehus, Oslo.
Tidsskr Nor Laegeforen. 1996 Jan 10;116(1):54-7.
An increasing demand for albumin in Oslo hospitals in the early 1990s instigated measures to reduce its use. During the autumn of 1993 a letter was sent to all doctors at Ullevål hospital informing them about the lack of documentation that albumin supplementation has a positive effect on outcome in critically ill with an albumin concentration of more than 20 g/l. In May 1994 the blood bank at Ullevål hospital stopped supplying 4% albumin solutions. A 20% reduction in use of albumin was observed after the letter of information, followed by a 50% reduction after the 4% solution was withdrawn. It is concluded that greater awareness of lack of information about the effects of albumin in critically ill patients has led to a more restrictive use of albumin. During the same period the use of polygeline increased, leading to the assumption that colloids other than albumin are being used for volume substitution.
20世纪90年代初，奥斯陆各医院对白蛋白的需求不断增加，这促使人们采取措施减少其使用。1993年秋，一封信被寄给了乌勒瓦尔医院的所有医生，告知他们缺乏证据表明对于白蛋白浓度超过20 g/l的重症患者，补充白蛋白对治疗结果有积极影响。1994年5月，乌勒瓦尔医院血库停止供应4%的白蛋白溶液。发出信息信后，白蛋白的使用量减少了20%，在4%的溶液停用后，又减少了50%。得出的结论是，对重症患者白蛋白作用信息缺乏的更多认识导致了对白蛋白的使用更加严格。同期聚明胶肽的使用增加，这使得人们认为除白蛋白外的胶体正被用于容量替代。
