[Structural-functional features of factor VIII (FVIII) and its role in the cascade system of blood coagulation].

Functions and structure of FVIII which is a cofactor in the internal way of blood coagulation are described as well as the known activation and inactivation mechanisms of FVIII following from its domain structure. The effect exerted by the Willibrandt factor (Wf), thrombin, factor X alpha(FX), activated protein C(APC) on the FVIII functions and interrelation between internal and external ways of blood coagulation in FVIII activation are discussed. The homologous structure of factors V and VIII which is a result of their cofactor action is described.