Gutsalo A E
Ukr Biokhim Zh (1978). 1995 Jul-Aug;67(4):12-23.
Functions and structure of FVIII which is a cofactor in the internal way of blood coagulation are described as well as the known activation and inactivation mechanisms of FVIII following from its domain structure. The effect exerted by the Willibrandt factor (Wf), thrombin, factor X alpha(FX), activated protein C(APC) on the FVIII functions and interrelation between internal and external ways of blood coagulation in FVIII activation are discussed. The homologous structure of factors V and VIII which is a result of their cofactor action is described.
描述了作为内源性凝血途径辅因子的FVIII的功能和结构，以及由其结构域结构推导得出的FVIII已知激活和失活机制。讨论了血管性血友病因子（Wf）、凝血酶、因子Xα（FX）、活化蛋白C（APC）对FVIII功能的影响以及FVIII激活过程中内源性和外源性凝血途径之间的相互关系。描述了因子V和VIII因辅因子作用而产生的同源结构。
