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MMP-8 (neutrophil collagenase) mRNA and aggrecanase cleavage products are present in normal and osteoarthritic human articular cartilage.

作者信息

Cole A A, Kuettner K E

机构信息

Department of Biochemistry, Rush Medical College at Rush-Presbyterian-St. Luke's Medical Center, Chicago, IL 60612, USA.

出版信息

Acta Orthop Scand Suppl. 1995 Oct;266:98-102.

PMID:8553870
Abstract
摘要

相似文献

1
MMP-8 (neutrophil collagenase) mRNA and aggrecanase cleavage products are present in normal and osteoarthritic human articular cartilage.MMP - 8（中性粒细胞胶原酶）信使核糖核酸和聚集蛋白聚糖酶裂解产物存在于正常和骨关节炎患者的人类关节软骨中。
Acta Orthop Scand Suppl. 1995 Oct;266:98-102.
2
Aggrecanase versus matrix metalloproteinases in the catabolism of the interglobular domain of aggrecan in vitro.体外软骨聚集蛋白聚糖球间结构域分解代谢中聚集蛋白聚糖酶与基质金属蛋白酶的比较
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3
Chondrocyte matrix metalloproteinase-8: up-regulation of neutrophil collagenase by interleukin-1 beta in human cartilage from knee and ankle joints.软骨细胞基质金属蛋白酶-8：白细胞介素-1β对人膝关节和踝关节软骨中中性粒细胞胶原酶的上调作用
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Differential patterns of response to doxycycline and transforming growth factor beta1 in the down-regulation of collagenases in osteoarthritic and normal human chondrocytes.强力霉素和转化生长因子β1对骨关节炎和正常人软骨细胞中胶原酶下调的不同反应模式
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J Orthop Res. 1997 Jan;15(1):94-100. doi: 10.1002/jor.1100150114.
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Enhanced cleavage of type II collagen by collagenases in osteoarthritic articular cartilage.骨关节炎关节软骨中胶原酶对II型胶原的切割作用增强。
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Selective enhancement of collagenase-mediated cleavage of resident type II collagen in cultured osteoarthritic cartilage and arrest with a synthetic inhibitor that spares collagenase 1 (matrix metalloproteinase 1).在培养的骨关节炎软骨中选择性增强胶原酶介导的驻留II型胶原的裂解，并使用一种对胶原酶1（基质金属蛋白酶1）无影响的合成抑制剂来阻止这种裂解。
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Chondrocyte matrix metalloproteinase-8. Human articular chondrocytes express neutrophil collagenase.软骨细胞基质金属蛋白酶-8。人关节软骨细胞表达中性粒细胞胶原酶。
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Peptides of type II collagen can induce the cleavage of type II collagen and aggrecan in articular cartilage.II型胶原蛋白肽可诱导关节软骨中II型胶原蛋白和聚集蛋白聚糖的裂解。
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Aggrecan degradation in human cartilage. Evidence for both matrix metalloproteinase and aggrecanase activity in normal, osteoarthritic, and rheumatoid joints.人软骨中的聚集蛋白聚糖降解。正常、骨关节炎和类风湿性关节中基质金属蛋白酶和聚集蛋白聚糖酶活性的证据。
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Mature bovine articular cartilage contains abundant aggrecan that is C-terminally truncated at Ala719-Ala720, a site which is readily cleaved by m-calpain.
成熟的牛关节软骨含有丰富的聚集蛋白聚糖，其C末端在Ala719 - Ala720处被截断，该位点很容易被m - 钙蛋白酶切割。
Biochem J. 2004 Aug 15;382(Pt 1):253-9. doi: 10.1042/BJ20040113.
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Analysis of aggrecan in human knee cartilage and synovial fluid indicates that aggrecanase (ADAMTS) activity is responsible for the catabolic turnover and loss of whole aggrecan whereas other protease activity is required for C-terminal processing in vivo.对人膝关节软骨和滑液中聚集蛋白聚糖的分析表明，聚集蛋白聚糖酶（ADAMTS）活性是整个聚集蛋白聚糖分解代谢转换和丢失的原因，而体内C端加工则需要其他蛋白酶活性。
Biochem J. 2001 Sep 15;358(Pt 3):615-26. doi: 10.1042/0264-6021:3580615.
5
Gene expression of matrix metalloproteinases 1, 3, and 9 by chondrocytes in osteoarthritic human knee articular cartilage is zone and grade specific.骨关节炎患者膝关节软骨中软骨细胞的基质金属蛋白酶1、3和9的基因表达具有区域和分级特异性。
Ann Rheum Dis. 1997 Sep;56(9):542-9. doi: 10.1136/ard.56.9.542.
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Aggrecan is degraded by matrix metalloproteinases in human arthritis. Evidence that matrix metalloproteinase and aggrecanase activities can be independent.在人类关节炎中，聚集蛋白聚糖被基质金属蛋白酶降解。有证据表明基质金属蛋白酶和聚集蛋白聚糖酶的活性可能是独立的。
J Clin Invest. 1996 Nov 15;98(10):2292-9. doi: 10.1172/JCI119040.