[肝硬化中的药代动力学]
[Pharmacokinetics in liver cirrhosis].
作者信息
Ackermann E
出版信息
Z Gesamte Inn Med. 1977 Jan 1;32(1):29-33.
PMID:855389
Abstract
In patients with severe hepatic parenchymal damage drug metabolism is presumably impaired. The reduced detoxification can not be sufficiently described in the postulated multicompartment model by determination of plasma half-life, because it depends on the physicochemical properties of the drugs. An increase of dihydroxybilic acids inhibits drug metabolism. Some drugs and also its metabolites formed in the liver induce hepatic cell injury including necrosis and therefore they are contraindicated in patients suffering from liver disease.
摘要
在严重肝实质损伤患者中，药物代谢可能受损。通过测定血浆半衰期，在假定的多室模型中无法充分描述解毒作用的降低，因为这取决于药物的物理化学性质。二羟基胆汁酸的增加会抑制药物代谢。一些药物及其在肝脏中形成的代谢产物会导致肝细胞损伤，包括坏死，因此肝病患者禁用这些药物。
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