谷胱甘肽S-转移酶GSTM3基因座多态性的鉴定：与GSTM1*A连锁的证据。
Identification of polymorphism at the glutathione S-transferase, GSTM3 locus: evidence for linkage with GSTM1*A.
作者信息
Inskip A, Elexperu-Camiruaga J, Buxton N, Dias P S, MacIntosh J, Campbell D, Jones P W, Yengi L, Talbot J A, Strange R C
机构信息
Department of Neurosurgery, North Staffordshire Hospital, Stoke-on-Trent, Staffordshire, U.K.
出版信息
Biochem J. 1995 Dec 15;312 ( Pt 3)(Pt 3):713-6. doi: 10.1042/bj3120713.
Allelism in the glutathione S-transferase, GSTM3 gene has been identified using PCR with specific primers to exon 6/exon 7. Sequencing showed the mutant GSTM3B allele to have a three-base deletion in intron 6 with a frequency of 0.158. The mutation generates a recognition sequence, 5'-AAGATA-3', for the negative transcription factor YY1. GSTM3B was significantly associated with GSTM1*A.
利用针对第6外显子/第7外显子的特异性引物进行聚合酶链反应（PCR），已在谷胱甘肽S-转移酶GSTM3基因中鉴定出复等位基因。测序显示，突变型GSTM3B等位基因在第6内含子中有一个三碱基缺失，频率为0.158。该突变产生了负转录因子YY1的识别序列5'-AAGATA-3'。GSTM3B与GSTM1*A显著相关。
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