Compton P A, Ling W, Charuvastra V C, Wesson D R
Los Angeles Addiction Treatment Research Center 90025, USA.
J Addict Dis. 1995;14(3):97-114. doi: 10.1300/J069v14n03_07.
The partial mu-opiate agonist, buprenorphine, is the subject of recent evaluation as a potential pharmacotherapy for cocaine dependence. This paper reviews the extant preclinical and clinical evidence of buprenorphine effectiveness in treating cocaine abuse, including data from our large methadone comparison trial and a smaller buprenorphine dose ranging study. Although buprenorphine appears to reduce cocaine self-administration in studies of non-opiate dependent animals, clinical evidence for the same response in opiate addicts abusing cocaine has not been demonstrated. Further efficacy trials should await preclinical demonstrations of effectiveness in samples with opiate and cocaine exposure.
部分μ-阿片受体激动剂丁丙诺啡是近期被评估作为可卡因依赖潜在药物治疗方法的研究对象。本文回顾了丁丙诺啡治疗可卡因滥用有效性的现有临床前和临床证据，包括来自我们大型美沙酮对比试验和一项较小规模丁丙诺啡剂量范围研究的数据。尽管在非阿片类依赖动物研究中，丁丙诺啡似乎能减少可卡因的自我给药，但在滥用可卡因的阿片类成瘾者中，尚未证实有相同反应的临床证据。进一步的疗效试验应等待在有阿片类和可卡因接触史的样本中进行临床前有效性验证。
