Stefánsson T, Ekbom A, Sparén P, Påhlman L
Cancer Epidemiology Unit, University Hospital, Uppsala, Sweden.
Eur J Surg. 1995 Oct;161(10):755-60.
To assess the incidence of underlying malignancy in patients with a diagnosis of diverticular disease of the colon.
Retrospective cohort study.
University hospital, Sweden.
7159 patients discharged from hospital with a first diagnosis of diverticulosis or diverticulitis in central Sweden 1965-1983.
The cohort was followed up for two years for the occurrence of cancer.
Cancer incidence.
A total of 372 cancer cases were identified standard incidence ratio = 2.4; 95% confidence interval 2.2 to 2.7). Sites at excess risk during the first year were: colon and rectum, pancreas, prostate, stomach, lymphatic and haemopoietic tissue, liver and bile ducts, ovary and lung, with the highest excess risk in the left colon (standard incidence ratio = 17.8; 95% CI 12.7 to 24.1).
Malignant diseases, especially colorectal cancer, are relatively common among patients with a clinical diagnosis of diverticulosis or diverticulitis of the colon. This may indicate a need for a change in current clinical practice.
评估诊断为结肠憩室病患者潜在恶性肿瘤的发生率。
回顾性队列研究。
瑞典大学医院。
1965年至1983年在瑞典中部首次诊断为憩室病或憩室炎并出院的7159例患者。
对该队列随访两年，观察癌症的发生情况。
癌症发病率。
共确定372例癌症病例（标准化发病率=2.4；95%置信区间2.2至2.7）。第一年风险增加的部位有：结肠和直肠、胰腺、前列腺、胃、淋巴和造血组织、肝脏和胆管、卵巢和肺，左结肠风险增加最高（标准化发病率=17.8；95%置信区间12.7至24.1）。
在临床诊断为结肠憩室病或憩室炎的患者中，恶性疾病尤其是结直肠癌相对常见。这可能表明当前临床实践需要改变。
