Harasaki H, Fukamachi K, Massiello A, Chen J F, Himley S C, Fukumura F, Muramoto K, Niu S, Wika K, Davies C R
Department of Biomedical Engineering, Cleveland Clinic Foundation, OH 44195, USA.
ASAIO J. 1994 Jul-Sep;40(3):M494-8.
A totally implantable, Cleveland Clinic-Nimbus total artificial heart (TAH) uses electrohydraulic energy conversion and an automatic left master-alternate mode control scheme, with a filling sensitivity of 1.0 l/min/mmHg and a maximum output of 9.5 l/min. The TAHs were tested in 12 calves for 1-120 days with normal major organ and blood cell function. Post-operative suppression of platelet aggregation recovered by the second post-operative week. The gelatin-coated pump surface generally was clean without any anticoagulants and free from infection. Embolism, which occurred in two cases, was caused by complications attributable to fungal infection in a Dacron graft and by thrombus formed around a jugular vein catheter. A system with a hybridized microcircuit controller in the interventricular space has been tested successfully in the three most recent cases, with a peak device surface temperature elevation of 6.5 degrees C. Heat effects were confined to the tissues immediately adjacent to the hottest spots. The carbon fiber-reinforced epoxy housing and 60 ml butyl rubber compliance chamber showed good tissue compatibility with a thin, fibrous tissue capsule. The transcutaneous energy transmission system and the internal battery functioned well as designed in the most recent animal implant.
一种完全可植入的克利夫兰诊所-宁布斯全人工心脏（TAH）采用电液压能量转换和自动左主-交替模式控制方案，充盈敏感度为1.0升/分钟/毫米汞柱，最大输出量为9.5升/分钟。这些全人工心脏在12头小牛身上进行了1至120天的测试，主要器官和血细胞功能正常。术后血小板聚集的抑制在术后第二周恢复。涂有明胶的泵表面通常干净，无需任何抗凝剂，且无感染。两例发生的栓塞是由涤纶移植物真菌感染引起的并发症以及颈静脉导管周围形成的血栓所致。在最近的三例病例中，一种在心室间隙采用混合微电路控制器的系统已成功测试，设备表面温度峰值升高6.5摄氏度。热效应局限于紧邻热点的组织。碳纤维增强环氧树脂外壳和60毫升丁基橡胶顺应腔与一层薄的纤维组织囊表现出良好的组织相容性。在最近的动物植入实验中，经皮能量传输系统和内置电池按设计运行良好。
