Holland A J, Treasure J, Coskeran P, Dallow J
Department of Psychiatry, University of Cambridge, England.
J Intellect Disabil Res. 1995 Oct;39 ( Pt 5):373-81. doi: 10.1111/j.1365-2788.1995.tb00541.x.
Over-eating and resultant obesity is well recognized as a central feature of the Prader-Willi Syndrome (PWS). The eating behaviour of 13 subjects with PWS was been studied retrospectively over a 28-day period and also by direct observation when given free access to food. Changing cognitions normally associated with food intake (e.g. changes in hunger) were assessed using visual analogue scales (VAS) and by asking subjects to rate photographs of particular foods. Eight out of 13 subjects (61%) with PWS had to have their access to food severely restricted. Ten (77%) ate excessive amounts when given free access to food, and although feelings of 'hunger', 'desire to eat' and 'fullness' changed in the expected direction, these changes were delayed, compared to a control group, and only occurred after eating a significantly greater amount of food. Ratings of 'hunger' and 'fullness' started to return to pre-meal levels sooner than in the controls. The present authors consider that PWS is an example of genetic obesity secondary to an impaired satiety response. These observations have important implications for treatment.
暴饮暴食及由此导致的肥胖是普拉德-威利综合征（PWS）的一个核心特征，这一点已得到广泛认可。对13名患有PWS的受试者在28天内的饮食行为进行了回顾性研究，并在他们可自由获取食物时进行了直接观察。使用视觉模拟量表（VAS）并要求受试者对特定食物的照片进行评分，以评估通常与食物摄入相关的认知变化（如饥饿感的变化）。13名患有PWS的受试者中有8名（61%）不得不对其食物获取进行严格限制。10名（77%）受试者在可自由获取食物时会过量进食，尽管“饥饿感”“进食欲望”和“饱腹感”的感觉按预期方向变化，但与对照组相比，这些变化出现延迟，且仅在进食了明显更多的食物后才出现。“饥饿感”和“饱腹感”的评分比对照组更快开始恢复到餐前水平。作者认为PWS是继发于饱腹感反应受损的遗传性肥胖的一个例子。这些观察结果对治疗具有重要意义。
