Leite-de-Moraes M C, Dy M
Université René Descartes, Paris, France.
Braz J Med Biol Res. 1995 Aug;28(8):903-5.
Differentiation of naive CD4+ lymphocytes into either Th1 or Th2 cells is influenced by the cytokine present during initial antigen priming. IL-4 is the critical element in the induction of Th2 response; however, its origin during a primary immune response is not well-defined. Here, a novel source of IL-4, the class I-selected CD4-CD8-TCR alpha beta+ T cells, potentially implicated in the development of specific Th2 immune cells, is reviewed.
初始CD4+淋巴细胞向Th1或Th2细胞的分化受初次抗原致敏期间存在的细胞因子影响。IL-4是诱导Th2反应的关键因素；然而，其在初次免疫反应中的来源尚不清楚。本文综述了IL-4的一种新来源，即I类选择的CD4-CD8-TCRαβ+T细胞，它可能与特定Th2免疫细胞的发育有关。
