Weiss M, Buldakova S, Dutova E
I.M. Sechenov Institute of Evolutionary Physiology and Biochemistry, St. Petersbourg, Russian Federation.
Brain Res. 1995 Oct 16;695(2):105-9. doi: 10.1016/0006-8993(95)00630-9.
An interaction of harmaline (HA), a beta-carboline, with benzodiazepine (Bzd) receptors, has been reported. HA perfusion induced a similar, although less potent, depressing effect as clonazepam (CLO) on the amplitude of the population spikes (PS) evoked by Schaffer collateral stimulation in the CA1 area of rat hippocampal slices. The suppressant effect of both CLO and HA on PS amplitude was reversed by simultaneous perfusion of the GABA antagonist picrotoxin. These results suggest that HA acts as a weak or partial agonist at Bzd receptors.
据报道，β-咔啉类物质哈尔满（HA）与苯二氮䓬（Bzd）受体存在相互作用。在大鼠海马切片CA1区，HA灌流对沙费尔侧支刺激诱发的群体峰电位（PS）幅度产生了与氯硝西泮（CLO）相似但效力较弱的抑制作用。同时灌流GABA拮抗剂荷包牡丹碱可逆转CLO和HA对PS幅度的抑制作用。这些结果表明，HA在Bzd受体上作为一种弱激动剂或部分激动剂发挥作用。
