延髓脊髓通路在氯米帕明对大鼠的抗伤害感受作用中的参与。
Involvement of bulbospinal pathways in the antinociceptive effect of clomipramine in the rat.
作者信息
Ardid D, Jourdan D, Mestre C, Villanueva L, Le Bars D, Eschalier A
机构信息
Equipe NPPUA, Laboratoire de Pharmacologie Médicale, Faculté de Médecine, Clermont-Ferrand, France.
出版信息
Brain Res. 1995 Oct 16;695(2):253-6. doi: 10.1016/0006-8993(95)00826-c.
The involvement of bulbospinal pathways in the antinociceptive effect of clomipramine in experimental pain was studied. The antinociceptive effect of the antidepressant (0.5 mg/kg), intravenously injected, was evaluated after a unilateral lesion of the dorsolateral funiculus. The results showed that this effect was suppressed only in the hindpaw ipsilateral to the dorsolateral funiculus lesion, and suggest that the antinociceptive effect of antidepressants needs intact descending inhibitory bulbospinal pathways.
研究了延髓脊髓通路在氯米帕明对实验性疼痛的抗伤害感受作用中的参与情况。在背外侧索单侧损伤后，评估了静脉注射抗抑郁药（0.5毫克/千克）的抗伤害感受作用。结果表明，这种作用仅在背外侧索损伤同侧的后爪中受到抑制，提示抗抑郁药的抗伤害感受作用需要完整的下行抑制性延髓脊髓通路。
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