Andersson T, Biörklund A, Landberg T, Akerman M, Aspegren K, Ingemansson S
Acta Otolaryngol. 1977 Mar-Apr;83(3-4):372-7. doi: 10.3109/00016487709128859.
Undifferentiated giant and spindle cell carcinoma is an unusual and high-grade malignant type of cancer of the thyroid. The results of surgical and/or radiotherapeutic treatment have been discouraging. Only a few patients respond to therapy, usually for a short time. Recently, a few reports have been published on the effect of chemotherapy or a combined treatment of surgery, radiotherapy and chemotherapy. In the present paper the results of combining radiotherapy and chemotherapy, 5-FU and cyclophosphamide, are reported. For the future a more aggressive approach is discussed. The therapy should include surgical resection of the main bulk of the tumour, followed by radiotherapy and concomitant chemotherapy and thereafter prolonged adjuvant chemotherapy.
未分化巨细胞和梭形细胞癌是一种罕见的、高级别甲状腺恶性肿瘤。手术和/或放射治疗的效果一直令人沮丧。只有少数患者对治疗有反应，而且通常持续时间较短。最近，有几篇关于化疗或手术、放疗和化疗联合治疗效果的报道发表。本文报道了放疗与化疗（5-氟尿嘧啶和环磷酰胺）联合应用的结果。对于未来，讨论了一种更积极的治疗方法。治疗应包括手术切除大部分肿瘤，随后进行放疗和同步化疗，然后进行长期辅助化疗。
