Koch K W
Institut für Biologische Informationsverarbeitung, Forschungszentrum Jülich, Germany.
Cell Calcium. 1995 Oct;18(4):314-21. doi: 10.1016/0143-4160(95)90027-6.
A decrease of cytoplasmic Ca(2+)-concentration in vertebrate photoreceptor cells after illumination is necessary for light adaptation. Although the mechanisms of adaptation is not completely understood, several Ca(2+)-dependent cellular processes have been discovered. Some involve calcium-binding proteins like recoverin, guanylyl cyclase-activating protein and calmodulin, and their target proteins rhodopsin kinase, guanylyl cyclase, the cGMP-gated channel, and NO synthase. The activity of several enzymes or channels is directly controlled by Ca2+ and does not involve calcium-binding proteins. These proteins are pyrophosphatase, protein kinase C and the cGMP-gated channel.
光照后脊椎动物光感受器细胞胞质Ca(2+)浓度降低是光适应所必需的。尽管适应机制尚未完全了解，但已发现了几种Ca(2+)依赖的细胞过程。一些涉及钙结合蛋白，如恢复蛋白、鸟苷酸环化酶激活蛋白和钙调蛋白，以及它们的靶蛋白视紫红质激酶、鸟苷酸环化酶、cGMP门控通道和一氧化氮合酶。几种酶或通道的活性直接受Ca2+控制，且不涉及钙结合蛋白。这些蛋白是焦磷酸酶、蛋白激酶C和cGMP门控通道。
