Sebit M B
Department of Psychiatry, University of Zimbabwe, Avondale, Harare, Zimbabwe.
Cent Afr J Med. 1995 Oct;41(10):315-22.
The objective of the study was to determine the prevalence and natural history of human immunodeficiency virus type 1 (HIV-1) associated psychiatric, neuropsychological and neurological abnormalities. A total of 408 subjects were recruited in Nairobi and Kinshasa. The study consisted of a cross sectional phase and a longitudinal follow up. Assessment was made by a data collection instrument including six modules. The intercentre and intracentre reliability in the use of the each module have been formally evaluated. The mean global score on the Montgomery-Asberg Depression Rating Scale was significantly higher in symptomatic seropositive individuals than in matched seronegative controls. In conclusion, these data suggest that the risk of subtle cognitive deficits may be increased in asymptomatic stages of HIV-1 infection.
该研究的目的是确定1型人类免疫缺陷病毒（HIV-1）相关的精神、神经心理和神经异常的患病率及自然史。在内罗毕和金沙萨共招募了408名受试者。该研究包括一个横断面阶段和一个纵向随访。通过一个包含六个模块的数据收集工具进行评估。每个模块使用中的中心间和中心内信度已得到正式评估。有症状的血清阳性个体在蒙哥马利-阿斯伯格抑郁评定量表上的平均总体得分显著高于配对的血清阴性对照。总之，这些数据表明，在HIV-1感染的无症状阶段，轻微认知缺陷的风险可能会增加。
