内源性一氧化氮不参与大鼠急性甲状旁腺激素诱导的低血压：高血压和甲状旁腺功能减退状态的影响。

Endogenous nitric oxide is not involved in acute parathyroid hormone-induced hypotension in rat: effect of hypertension and hypoparathyroid status.

作者信息

Schleiffer R, Pernot F, Gairard A

机构信息

CNRS URA 600, Faculté de Pharmacie, Université Louis Pasteur, Strasbourg, France.

出版信息

Horm Metab Res. 1995 Sep;27(9):415-8. doi: 10.1055/s-2007-979990.

DOI:10.1055/s-2007-979990

PMID:8557240

Abstract

The present study investigated the acute hypotensive effect of parathyroid hormone (PTH) in anesthetized adult spontaneously hypertensive (SHR) and normotensive Wistar-Kyoto rats. Furthermore, in order to determine the possible contribution of nitric oxide (NO), a mediator of endothelium-dependent vasorelaxation, hypotensive responses to PTH were obtained in the presence of NG-nitro-L-arginine methyl ester (L-NAME), an inhibitor of NO synthesis. The hypotensive effect of PTH (expressed as % of baseline blood pressure) was similar for the two strains. In the presence of L-NAME (18.5 mumol/kg), both strains demonstrated a similar hypotensive response to PTH, indicating that the hypotensive response to PTH is NO-independent.

摘要

本研究调查了甲状旁腺激素（PTH）对麻醉的成年自发性高血压（SHR）大鼠和血压正常的Wistar-Kyoto大鼠的急性降压作用。此外，为了确定内皮依赖性血管舒张介质一氧化氮（NO）的可能作用，在一氧化氮合成抑制剂NG-硝基-L-精氨酸甲酯（L-NAME）存在的情况下，获得了对PTH的降压反应。PTH的降压作用（以基线血压的百分比表示）在两种品系中相似。在L-NAME（18.5 μmol/kg）存在的情况下，两种品系对PTH均表现出相似的降压反应，表明对PTH的降压反应不依赖于NO。