Sainz J, Figueroa K, Baser M E, Pulst S M
Neurogenetics Laboratory, Cedars-Sinai Medical Center, University of California at Los Angeles 90048, USA.
Hum Genet. 1996 Jan;97(1):121-3. doi: 10.1007/BF00218846.
Vestibular schwannomas (VSs) are common benign tumors of Schwann cell origin and are frequently found in patients with neurofibromatosis type 2 (NF2). We analyzed 15 sporadic VSs for mutations in the tumors, two of which contained loss of heterozygosity (LOH). One of the tumors contained a novel mutation, a 19-bp deletion in exon 4. The two other tumors contained an identical mutation, a complete exon 4 deletion. The exon 4 deletion represents the second most frequently reported mutation of the NF2 gene in VSs.
