前列腺素合成抑制剂在化学诱导癫痫发作中的作用。
Role of prostaglandin synthesis inhibitors on chemically induced seizures.
作者信息
Bhaduri J, Hota D, Acharya S B
机构信息
Department of Pharmacology, Banaras Hindu University, Varanasi, India.
出版信息
Indian J Exp Biol. 1995 Sep;33(9):677-81.
PMID:8557311
Abstract
The study was conducted to find out the possible role of prostaglandin synthesis inhibitors on different parameters of chemically induced seizures in albino mice. The results suggest that prostaglandins have a proconvulsant activity. Augmentation of central dopamine and serotonin levels is partly responsible for the inhibitory effect of prostaglandin synthesis inhibitors on chemically induced seizures.
摘要
进行该研究以查明前列腺素合成抑制剂对化学诱导的白化病小鼠癫痫发作不同参数的可能作用。结果表明，前列腺素具有促惊厥活性。中枢多巴胺和5-羟色胺水平的升高部分解释了前列腺素合成抑制剂对化学诱导癫痫发作的抑制作用。
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