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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Grahame R, Simmonds H A, Cameron J S, Cadenhead A

Adv Exp Med Biol. 1977;76B:312-9. doi: 10.1007/978-1-4684-3285-5_47.

The important fact which emerges from these studies both without and with dietary purine supplementation is that thiopurinol dose possess apparent in vivo xanthine oxidase inhibitory activity but the dose must be increased well above therapeutic levels for this effect to manifest. 2. The considerable reduction in total endogenous urinary purine excretion at these high doses substantiates an additional inhibitory effect of thiopurinol on de novo purine synthesis. 3. Thiopurinol, like its analogue allopurinol, is also capable of reducing the absorption of dietary purine administered in the form of guanine in the pig.

这些在补充和不补充膳食嘌呤情况下进行的研究得出的重要事实是，硫嘌呤醇剂量具有明显的体内黄嘌呤氧化酶抑制活性，但必须将剂量提高到远高于治疗水平才能显现出这种效果。2. 在这些高剂量下，内源性尿嘌呤总排泄量显著减少，证实了硫嘌呤醇对嘌呤从头合成的额外抑制作用。3. 硫嘌呤醇与其类似物别嘌呤醇一样，也能够减少猪体内以鸟嘌呤形式给予的膳食嘌呤的吸收。

Grahame R, Simmonds H A, Cameron J S, Cadenhead A

Adv Exp Med Biol. 1977;76B:312-9. doi: 10.1007/978-1-4684-3285-5_47.

The important fact which emerges from these studies both without and with dietary purine supplementation is that thiopurinol dose possess apparent in vivo xanthine oxidase inhibitory activity but the dose must be increased well above therapeutic levels for this effect to manifest. 2. The considerable reduction in total endogenous urinary purine excretion at these high doses substantiates an additional inhibitory effect of thiopurinol on de novo purine synthesis. 3. Thiopurinol, like its analogue allopurinol, is also capable of reducing the absorption of dietary purine administered in the form of guanine in the pig.

这些在补充和不补充膳食嘌呤情况下进行的研究得出的重要事实是，硫嘌呤醇剂量具有明显的体内黄嘌呤氧化酶抑制活性，但必须将剂量提高到远高于治疗水平才能显现出这种效果。2. 在这些高剂量下，内源性尿嘌呤总排泄量显著减少，证实了硫嘌呤醇对嘌呤从头合成的额外抑制作用。3. 硫嘌呤醇与其类似物别嘌呤醇一样，也能够减少猪体内以鸟嘌呤形式给予的膳食嘌呤的吸收。