核糖基化利福平及其衍生物的结构测定：分枝杆菌菌株产生的利福平新的失活代谢产物
Structure determination of ribosylated rifampicin and its derivative: new inactivated metabolites of rifampicin by mycobacterial strains.
作者信息
Morisaki N, Kobayashi H, Iwasaki S, Furihata K, Dabbs E R, Yazawa K, Mikami Y
机构信息
Institute of Molecular and Cellular Biosciences, University of Tokyo, Japan.
出版信息
J Antibiot (Tokyo). 1995 Nov;48(11):1299-303. doi: 10.7164/antibiotics.48.1299.
PMID:8557572
Abstract
Rifampicin (I) was converted into two inactivated products RIP-Ma and RIP-Mb by Mycobacterium smegmatis DSM43756. MS, NMR and chromatographic analysis showed the compounds to be 3-formyl-23-[O-(alpha-D-ribofuranosyl)]rifamycin SV (6) and 23-[O-(alpha-D-ribofuranosyl)]rifampicin (7), respectively.
摘要
利福平（I）被耻垢分枝杆菌DSM43756转化为两种失活产物RIP-Ma和RIP-Mb。质谱、核磁共振和色谱分析表明，这两种化合物分别为3-甲酰基-23-[O-(α-D-呋喃核糖基)]利福霉素SV（6）和23-[O-(α-D-呋喃核糖基)]利福平（7）。
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