Mehta A C, Hart-Davies S, Kay E A
Department of Pharmacy, General Infirmary, Leeds, Yorkshire, U.K.
J Clin Pharm Ther. 1995 Aug;20(4):243-5. doi: 10.1111/j.1365-2710.1995.tb00656.x.
The in vitro dissolution rates of 5 and 10 mg nifedipine capsules from eight suppliers were measured in simulated gastric fluid using the rotating paddle apparatus. A total of fourteen products were tested and the performance was found to be satisfactory for all products (> 80% dissolution in 20 min).
使用旋转桨法在模拟胃液中测定了来自八个供应商的5毫克和10毫克硝苯地平胶囊的体外溶出率。总共测试了14种产品,发现所有产品的性能均令人满意(20分钟内溶出率>80%)。