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Influence of urapidil on cerebrospinal fluid pressure in humans with uncompromised intracranial compliance.

作者信息

Hörmann C, Luz G, Langmayr J, Schalow S, Benzer A

机构信息

Department of Anaesthesia, University Hospital, Innsbruck, Austria.

出版信息

Intensive Care Med. 1995 Oct;21(10):853-5. doi: 10.1007/BF01700972.

DOI:10.1007/BF01700972
PMID:8557877
Abstract

OBJECTIVE

Determine the influence of urapidil on mean lumbar cerebrospinal fluid pressure (CSFP), mean arterial pressure (MAP), mean central venous pressure (CVP) and heart rate (HR) in awake humans without any evidence of cerebral or cardiovascular disease.

DESIGN

Open, single-dose volunteer study.

INTERVENTIONS

CSFP was measured via a spinal needle after i.v. injection of a single dose of 0.2 mg kg-1 urapidil in six volunteers (2 female, 4 male).

MEASUREMENTS AND RESULTS

After administration of urapidil, CSFP increased from 7 +/- 1 mmHg to 10 +/- 1 mmHg (p < 0.05), MAP decreased from 88 +/- 7 mmHg to 74 +/- 5 mmHg (p < 0.05), CPP decreased from 81 +/- 7 mmHg to 64 +/- 5 mmHg (p < 0.05) and CVP decreased from 0 +/- 1 mmHg to -3 +/- 1 mmHg (p < 0.05).

CONCLUSION

Our data suggest that in humans with presumed normal intracranial compliance the administration of urapidil causes a small but statistically significant increase in CSFP due to a parallel decrease in MAP.

摘要

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引用本文的文献

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本文引用的文献

1
The influence of urapidil, a new antihypertensive agent, on cerebral perfusion pressure in dogs with and without intracranial hypertension.
Intensive Care Med. 1983;9(3):123-6. doi: 10.1007/BF01772578.
2
Influence of urapidil on intracranial pressure and intracranial compliance in dogs.乌拉地尔对犬颅内压及颅内顺应性的影响。
Br J Anaesth. 1983 May;55(5):443-8. doi: 10.1093/bja/55.5.443.
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Cerebral blood flow during and after hyperventilation.
Arch Neurol. 1970 Nov;23(5):394-403. doi: 10.1001/archneur.1970.00480290014002.
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Comparison of phentolamine and urapidil in controlling acute intra-operative hypertension in patients subjected to coronary artery bypass surgery.
Eur J Anaesthesiol. 1985 Mar;2(1):21-7.
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[Modification of intracranial pressure by urapidil following experimental cold lesions in the cat].[猫实验性冷损伤后乌拉地尔对颅内压的影响]
Anasth Intensivther Notfallmed. 1986 Aug;21(4):218-22.
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Permeation of the blood-brain barrier by urapidil and its influence on intracranial pressure in man in the presence of compromised intracranial dynamics.乌拉地尔对血脑屏障的通透性及其在颅内动力学受损情况下对人体颅内压的影响。
J Hypertens Suppl. 1988 Dec;6(2):S63-4.
7
Urapidil and some analogues with hypotensive properties show high affinities for 5-hydroxytryptamine (5-HT) binding sites of the 5-HT1A subtype and for alpha 1-adrenoceptor binding sites.乌拉地尔及一些具有降压特性的类似物对5-HT1A亚型的5-羟色胺（5-HT）结合位点和α1-肾上腺素能受体结合位点表现出高亲和力。
Naunyn Schmiedebergs Arch Pharmacol. 1987 Dec;336(6):597-601. doi: 10.1007/BF00165749.
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Urapidil-induced increase of the intracranial pressure in head-trauma patients.
Intensive Care Med. 1990;16(4):272-4. doi: 10.1007/BF01705166.