Yazan Y, Demirel M, Güler E
Anadolu University, Faculty of Pharmacy, Department of Pharmaceutical Technology, Eskişehir, Turkey.
J Microencapsul. 1995 Nov-Dec;12(6):601-7. doi: 10.3109/02652049509006790.
Salbutamol sulphate is a sympathomimetic amine having a rather short plasma half-life. Aiming to achieve sustained release of this drug through microencapsulation, the coacervation method with a 1:1 core-shell ratio was used. In vitro release rate experiments were performed on the microcapsules prepared using ethyl cellulose as the coating agent and compared to the results of intact drug, the tabletted microcapsules and a commercial tablet. The release rate of salbutamol sulphate could be controlled through microencapsulation. The time for the 50% release of the drug was 15 and 90 min for the tabletted microcapsules and microcapsules respectively. The specific surface area of the intact drug was 0.35 m2/cc while it reduced to 0.06 m2/cc after encapsulation.
硫酸沙丁胺醇是一种拟交感神经胺，其血浆半衰期相当短。为了通过微囊化实现该药物的持续释放，采用了核壳比为1:1的凝聚法。对以乙基纤维素为包衣剂制备的微囊进行了体外释放速率实验，并与完整药物、压片微囊和市售片剂的结果进行了比较。硫酸沙丁胺醇的释放速率可通过微囊化来控制。药物50%释放的时间，压片微囊和微囊分别为15分钟和90分钟。完整药物的比表面积为0.35平方米/立方厘米，而包囊后降至0.06平方米/立方厘米。
