Feldman E B, Watt R, Feldman D S
Am J Dig Dis. 1977 May;22(5):415-8. doi: 10.1007/BF01071888.
Effects of bile salts on intestinal transfer differ in diverse animal preparations exposed to various bile acids. Radiolabeled glucose influx into rat jejunum in vitro was studied in buffer and compared to taurodeoxycholate, taurochenodeoxycholate, taurocholate, and deoxycholate. Jejunum was obtained from intact, bile-diverted, and colestipol-treated rats and in similar categories after abdominal x-irradiation. Taurodeoxycholate but not taurocholate inhibited glucose influx only in bile-fistula and colestipol-treated rats. Bile diversion increased and colestipol decreased glucose uptake from buffer. Added inhibitory effects of irradiation and bile salts were seen in bile-fistula animals. These data suggest that normal exposure to bile is chronically inhibiting jejunal glucose transport and that dihydroxy bile salts are responsible for this effect. They do not provide an explanation for the role of bile in the intestinal radiation syndrome.
在暴露于各种胆汁酸的不同动物制剂中，胆盐对肠道转运的影响有所不同。在缓冲液中研究了放射性标记的葡萄糖流入大鼠空肠的情况，并与牛磺脱氧胆酸盐、牛磺鹅脱氧胆酸盐、牛磺胆酸盐和脱氧胆酸盐进行了比较。空肠取自完整、胆汁分流和考来烯胺处理的大鼠，以及腹部X线照射后的类似类别大鼠。仅在胆瘘和考来烯胺处理的大鼠中，牛磺脱氧胆酸盐而非牛磺胆酸盐抑制了葡萄糖流入。胆汁分流增加了缓冲液中的葡萄糖摄取，而考来烯胺则降低了葡萄糖摄取。在胆瘘动物中观察到了辐射和胆盐的附加抑制作用。这些数据表明，正常暴露于胆汁会长期抑制空肠葡萄糖转运，并且二羟基胆盐是造成这种影响的原因。它们并未对胆汁在肠道辐射综合征中的作用做出解释。
