Fisahn J, Lucas W J
Institut für Genbiologische Forschung GmbH, Berlin, Germany.
J Membr Biol. 1995 Oct;147(3):275-81. doi: 10.1007/BF00234525.
Pattern formation mechanisms in developing organisms determine cellular differentiation and function. However, the components that interact during the manifestation of a spatial pattern are in general unknown. Characean algae represent a model system to study pattern formation. These algae develop alternating acid and alkaline transport domains that influence the pattern of growth. In the present study, it will be demonstrated that a diffusion mechanism is implicated in acid and alkaline domain formation and this growth pattern. Experiments on the characean growth pattern were performed that resulted in pronounced, however, unpredictable modifications in the original pattern. A major component involved in this pattern-forming mechanism emerged from the nonlinear kinetics of the H(+)-ATPase that is located in the plasma membrane of these algae. Based on these kinetics, a mathematical model was developed and numerically analyzed. As a result, the contribution of a diffusional component to the characean acid/alkaline pattern appeared most likely.
发育中的生物体中的模式形成机制决定了细胞分化和功能。然而，在空间模式表现过程中相互作用的成分通常是未知的。轮藻是研究模式形成的一个模型系统。这些藻类会形成交替的酸和碱转运区域，这些区域会影响生长模式。在本研究中，将证明一种扩散机制与酸和碱区域的形成以及这种生长模式有关。对轮藻生长模式进行了实验，结果导致原始模式出现明显但不可预测的改变。参与这种模式形成机制的一个主要成分来自位于这些藻类质膜上的H(+)-ATP酶的非线性动力学。基于这些动力学，建立了一个数学模型并进行了数值分析。结果，扩散成分对轮藻酸/碱模式的贡献似乎最有可能。
