Ruiz-Cerdá J L, Hernández M, Gomis F, Vera C D, Kimler B F, O'Connor J E, Jiménez-Cruz F
Department of Urology, La Fe University Hospital, Faculty of Medicine, University of Valencia, Spain.
J Urol. 1996 Feb;155(2):459-65.
A retrospective study was performed on 108 patients with localized renal cell carcinoma (pT1 to 3a N0M0) to determine whether ploidy and nuclear morphometry are independent predictive factors in addition to stage and grade.
Deoxyribonucleic acid (DNA) content was analyzed by flow cytometry and nuclear morphometry characterized by 5 nuclear descriptors. A Cox proportional hazards regression model was used to identify significant prognostic factors for disease progression.
A model combining tumor stage and grade, DNA ploidy and nuclear minor axis was chosen as optimal with risk of disease progression increased with increasing tumor stage and grade, DNA aneuploidy and increasing nuclear minor axis.
This improved ability to predict disease progression in localized renal cell carcinoma may have important clinical use.
对108例局限性肾细胞癌（pT1至3a N0M0）患者进行回顾性研究，以确定除分期和分级外，倍性和核形态计量学是否为独立的预测因素。
通过流式细胞术分析脱氧核糖核酸（DNA）含量，并用5个核描述符表征核形态计量学。采用Cox比例风险回归模型确定疾病进展的显著预后因素。
选择一个结合肿瘤分期和分级、DNA倍性和核短轴的模型为最佳模型，疾病进展风险随肿瘤分期和分级增加、DNA非整倍体以及核短轴增加而升高。
这种在局限性肾细胞癌中预测疾病进展的能力提高可能具有重要的临床应用价值。
