Barrington J W, Fraylin L, Fish R, Shelley M, Stephenson T P
Department of Urology, Cardiff Royal Infirmary and Research Laboratories, Velindre NHS Trust Hospital, South Glamorgan, United Kingdom.
J Urol. 1996 Feb;155(2):468-70.
We determined whether basic fibroblast growth factor is elevated in the urine of patients who have undergone clam ileocystoplasty.
An immunoassay technique was used to measure urinary basic fibroblast growth factor in 50 patients equally divided between those with and without neuropathy who had undergone clam enterocystoplasty. The results were compared with urinary basic fibroblast growth factor concentrations from 25 healthy age and sex matched volunteers.
There is a highly significant elevation of urinary basic fibroblast growth factor in clam enterocystoplasty patients compared to controls, which is not related to the presence or absence of infection. There is no difference between those with and without neuropathy.
Elevated levels of basic fibroblast growth factor are an important consideration in the malignant potential of the clam procedure.
我们确定在接受回肠膀胱扩大术的患者尿液中碱性成纤维细胞生长因子是否升高。
采用免疫测定技术，对50例行回肠膀胱扩大术的患者进行尿液碱性成纤维细胞生长因子测量，这些患者按有无神经病变分为两组，每组25例。将结果与25名年龄和性别匹配的健康志愿者的尿液碱性成纤维细胞生长因子浓度进行比较。
与对照组相比，回肠膀胱扩大术患者尿液碱性成纤维细胞生长因子显著升高，且与有无感染无关。有无神经病变的患者之间无差异。
碱性成纤维细胞生长因子水平升高是回肠膀胱扩大术潜在恶性风险的一个重要考量因素。
