Faerber G J
Section of Urology, University of Michigan Medical Center, Veteran's Administration Medical Center, Ann Arbor, USA.
J Urol. 1996 Feb;155(2):512-4.
The safety and efficacy of collagen injection therapy for the treatment of type I stress urinary incontinence were determined.
A total of 12 women 68 to 85 years old (mean age 76) with type I stress urinary incontinence underwent collagen injection. Incontinence was subjectively categorized as grades 0 to 3, and Valsalva leak point pressures were measured before and after injection.
At a mean of 10.3 months (range 3 to 24) 10 of the 12 women (83%) were cured, while the remaining 2 noticed subjective improvement in incontinence. Average number of injections per patient was 1.25 (1 injection in 9 and 2 in 3), average total collagen injected per patient was 2.2 cc (range 1.0 to 3.5) and average increase in Valsalva leak point pressure after collagen injection was 22 cm. water (range 0 to 40).
Collagen injection appears to be an effective alternative method for the treatment of type I stress urinary incontinence in elderly women.
确定胶原蛋白注射疗法治疗Ⅰ型压力性尿失禁的安全性和有效性。
12名年龄在68至85岁（平均年龄76岁）的Ⅰ型压力性尿失禁女性接受了胶原蛋白注射。尿失禁主观分为0至3级，并在注射前后测量瓦尔萨尔瓦漏尿点压力。
平均10.3个月（范围3至24个月）时，12名女性中有10名（83%）治愈，其余2名尿失禁有主观改善。每位患者平均注射次数为1.25次（9名患者注射1次，3名患者注射2次），每位患者平均注射的胶原蛋白总量为2.2立方厘米（范围1.0至3.5），胶原蛋白注射后瓦尔萨尔瓦漏尿点压力平均增加22厘米水柱（范围0至40）。
胶原蛋白注射似乎是治疗老年女性Ⅰ型压力性尿失禁的一种有效替代方法。
