Jacobsen S J, Girman C J, Guess H A, Rhodes T, Oesterling J E, Lieber M M
Department of Health Sciences Research (Section of Clinical Epidemiology), Mayo Clinic, Rochester, Minnesota 55905, USA.
J Urol. 1996 Feb;155(2):595-600. doi: 10.1016/s0022-5347(01)66461-9.
We report the results of 3 contacts during 42 months of The Olmsted County Study of Urinary Symptoms and Health Status Among Men, a longitudinal cohort study of men 40 to 79 years old that was initiated in 1990 to describe changes in lower urinary tract symptom severity.
At baseline and followup, men completed questionnaires that elicited urinary symptom severity with questions nearly identical to those of the American Urological Association symptom index:
Overall, there was an average increase in American Urological Association symptom index of approximately 0.18 (95% confidence interval 0.13 to 0.24) points per year of followup. The average annual symptom score slope and variability in slope increased with patient age at baseline from a mean of 0.05 +/- 1.06 (standard deviation) per year among men in the forties to 0.44 +/- 1.35 per year for men in the sixties, and decreased to 0.14 +/- 1.42 per year for men in the seventies. The age-related changes in symptom severity mirror previous estimates of prostatic growth from autopsy prevalence studies.
These results demonstrate a slow but measurable progression in urinary symptom severity among community dwelling men for 42 months of followup.
我们报告了在奥尔姆斯特德县男性泌尿系统症状与健康状况研究的42个月期间3次随访的结果，该研究是一项针对40至79岁男性的纵向队列研究，始于1990年，旨在描述下尿路症状严重程度的变化。
在基线和随访时，男性完成了问卷调查，这些问卷通过与美国泌尿外科学会症状指数中几乎相同的问题来引出泌尿系统症状严重程度。
总体而言，随访期间美国泌尿外科学会症状指数平均每年增加约0.18分（95%置信区间为0.13至0.24）。平均每年症状评分斜率以及斜率的变异性随着基线时患者年龄的增加而增加，从四十多岁男性的平均每年0.05±1.06（标准差）增加到六十多岁男性的平均每年0.44±1.35，七十多岁男性则降至平均每年0.14±1.42。症状严重程度与年龄相关的变化反映了之前尸检患病率研究对前列腺生长的估计。
这些结果表明，在为期42个月的随访中，社区居住男性的泌尿系统症状严重程度呈缓慢但可测量的进展。
