一种用于研究钙蛋白酶-钙蛋白酶抑制蛋白系统的新型大鼠模型。

A new rat model for studying the calpain-calpastatin system.

作者信息

Soldati L P, Barber B R, Salardi S, Molinari I, Bianchi G

机构信息

Department of Sciences and Biomedical Technologies, University of Milan, Italy.

出版信息

Lab Anim. 1995 Oct;29(4):420-6. doi: 10.1258/002367795780740032.

DOI:10.1258/002367795780740032

PMID:8558825

Abstract

A recombinant rat strain--Milan low-calpastatin strain (MLCS)--was derived from Milan hypertensive (MHS/Gib) and Milan normotensive (MNS/Gib) strains. The MLCS rats have normal blood pressure and low calpastatin activity, and this strain is proposed as a model for studies of the calpain-calpastatin system, which is involved in important cellular mechanisms. Calpastatin polymorphism was observed in 10 different strains of laboratory rats and a single locus hypothesis is suggested as the mode of inheritance.

摘要

一种重组大鼠品系——米兰低钙蛋白酶抑制蛋白品系（MLCS）——源自米兰高血压品系（MHS/Gib）和米兰正常血压品系（MNS/Gib）。MLCS大鼠血压正常但钙蛋白酶抑制蛋白活性较低，该品系被提议作为研究钙蛋白酶 - 钙蛋白酶抑制蛋白系统的模型，该系统涉及重要的细胞机制。在10种不同的实验大鼠品系中观察到了钙蛋白酶抑制蛋白多态性，并提出单基因座假说是其遗传模式。