Van Calenbergh F, Van de Laar A, Plets C, Goffin J, Casaer P
Department of Neurosurgery, University Hospital Gasthuisberg, Catholic University of Leuven, Belgium.
Neurosurgery. 1995 Nov;37(5):894-8. doi: 10.1227/00006123-199511000-00007.
Cerebellar mutism has been reported after surgery for posterior fossa tumors in children and, rarely, in adults. The pathogenesis of this syndrome remains unclear, and controversy exists regarding whether it is a purely psychogenic disorder or an organic syndrome. The anatomical substrate for the mutism also remains unknown. We encountered five cases of postoperative transient cerebellar mutism in a consecutive series of 63 children with posterior fossa tumors. These cases were analyzed and compared with the patients without mutism to find predictive factors for the occurrence of mutism, with the hope of elucidating further the pathophysiological mechanism. The most significant finding was the presence in all cases of a period of cerebellar dysarthria after resolution of the muteness. We, therefore, believe that cerebellar mutism is an extreme form of dysarthria, rather than a real cognitive deficit or a psychological disturbance.
儿童后颅窝肿瘤手术后曾有关于小脑缄默症的报道,成人中则较为罕见。该综合征的发病机制尚不清楚,对于它是一种纯粹的心因性障碍还是器质性综合征存在争议。缄默症的解剖学基础也尚不明确。在连续63例患有后颅窝肿瘤的儿童中,我们遇到了5例术后短暂性小脑缄默症病例。对这些病例进行分析,并与无缄默症的患者进行比较,以找出缄默症发生的预测因素,希望能进一步阐明其病理生理机制。最显著的发现是在所有病例中,缄默症缓解后都存在一段小脑构音障碍期。因此,我们认为小脑缄默症是构音障碍的一种极端形式,而非真正的认知缺陷或心理障碍。