Check J H, Peymer M, Lurie D, Suryanarayan C
Department of Obstetrics and Gynecology, University of Medicine and Dentistry of New Jersey-Robert Wood Johnson Medical School at Camden, Cooper Hospital/University Medical Center, USA.
Obstet Gynecol. 1996 Feb;87(2):291-6. doi: 10.1016/0029-7844(95)00398-3.
To investigate the relationship of early follicular phase serum LH levels and pregnancy rates in ovulatory women with regular menstrual cycles.
One hundred consecutive couples seeking help for infertility who had bilateral tubal patency, a minimum motile sperm-density-of 2.5 million/mL, and regular menstrual cycles were enrolled in the study. Baseline serum measurements of LH, FSH, and testosterone were obtained before treatment. Patients were treated with clomiphene citrate, human menopausal gonadotropin, or progesterone supplementation, as needed. Treatment continued for 6 months or until conception occurred. The 6-month pregnancy rates were correlated with baseline early follicular phase serum levels and age.
The 6-month viable pregnancy rates did not decrease with an increase in baseline LH serum levels; they were 50% if LH was 10 mIU/L or less, 15.3% if LH was 11-20 mIU/mL, and 71.4% if LH was more than 20 mIU/mL. The 16.7% pregnancy rate in women whose baseline FSH exceeded 25 mIU/mL was significantly lower than the 56.3% rate in women whose FSH was 25 mIU/mL or lower. The pregnancy rates also declined significantly with age. When we controlled for age, FSH did not have an independent effect on conception rates.
Early follicular phase serum levels of LH were not associated with pregnancy rates in infertile ovulatory women who were treated with progesterone in the luteal phase when needed. However, early follicular levels of FSH and age at treatment were found to be related to pregnancy rates.
探讨月经周期规律的排卵女性卵泡早期血清促黄体生成素（LH）水平与妊娠率之间的关系。
连续纳入100对因不育前来寻求帮助的夫妇，这些夫妇双侧输卵管通畅，精子最低活动密度为250万/mL，月经周期规律。在治疗前获取LH、促卵泡生成素（FSH）和睾酮的基线血清测量值。根据需要，患者接受枸橼酸氯米芬、人绝经期促性腺激素或孕激素补充治疗。治疗持续6个月或直至受孕。将6个月的妊娠率与基线卵泡早期血清水平及年龄进行相关性分析。
6个月的活产妊娠率并未随基线LH血清水平的升高而降低；当LH为10 mIU/L或更低时，妊娠率为50%；当LH为11 - 20 mIU/mL时，妊娠率为15.3%；当LH超过20 mIU/mL时，妊娠率为71.4%。基线FSH超过25 mIU/mL的女性妊娠率为16.7%，显著低于FSH为25 mIU/mL或更低的女性的56.3%的妊娠率。妊娠率也随年龄显著下降。当我们控制年龄因素后，FSH对受孕率没有独立影响。
对于在黄体期按需接受孕激素治疗的不育排卵女性，卵泡早期血清LH水平与妊娠率无关。然而，发现卵泡早期FSH水平及治疗时的年龄与妊娠率有关。
