单端孢霉烯族真菌毒素对真核生物蛋白质合成起始、延伸和终止的抑制作用。
Inhibition of initiation, elongation, and termination of eukaryotic protein synthesis by trichothecene fungal toxins.
作者信息
Cundliffe E, Davies J E
出版信息
Antimicrob Agents Chemother. 1977 Mar;11(3):491-9. doi: 10.1128/AAC.11.3.491.
Abstract
The 12,13-epoxytrichothecenes, specific inhibitors of protein synthesis in eukaryotes, can be subdivided further in terms of their mode of action. In addition to the I-type (initiation inhibitors) and E-types (elongation inhibitors), we found that some E-types apparently exhibit inhibition of chain termination at low concentrations. The nature of substituents on C4 may determine the type of inhibitory activity observed.
摘要
12,13-环氧单端孢霉烯族毒素是真核生物中蛋白质合成的特异性抑制剂，根据其作用方式可进一步细分。除了I型（起始抑制剂）和E型（延伸抑制剂），我们发现一些E型在低浓度时明显表现出对链终止的抑制作用。C4上取代基的性质可能决定所观察到的抑制活性类型。
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