Rodríguez J N, Moreno M V, Martino M L, Fernández-Jurado A, Uceda M E, Prados D
Servicio de Hematología, Hospital Juan Ramón, Jiménez, Huelva.
Rev Clin Esp. 1995 Nov;195(11):769-72.
Primary testicular lymphoma (PTL) is the most frequently diagnosed testicular tumor in men over 60 years, in spite of this circumstance it is a rare process. Two cases of PTL are reported, the first one in a child and the second in an adult. Both cases were intermediate grade lymphoma and had low stage (IEA), presenting initially as an enlargement of the testicle as the only symptom, the second case presented involvement by contiguity of the abdominal muscles. Immunohistological markers showed T nature in the first case, and B in the second. The treatment applied in both cases was orchiectomy and systemic chemotherapy using COP-BLAM/IMVP-16, in the child prophylaxis of the central nervous system using methotrexate was made. Response to treatment was good, the first patient achieved complete remission and his survival at present is 24 months, the second patient died 5 month after diagnosis due to stroke without having completed chemotherapy but with an important reduction of the tumoral mass. A review of the literature on clinical, diagnostic and therapeutic issues is made.
原发性睾丸淋巴瘤（PTL）是60岁以上男性中最常被诊断出的睾丸肿瘤，尽管如此，它仍是一种罕见的病症。本文报告了两例PTL，第一例发生在儿童，第二例发生在成人。两例均为中度淋巴瘤且分期较低（IEA），最初均仅表现为睾丸肿大这一症状，第二例还出现了腹肌连续性受累。免疫组织学标记显示，第一例为T细胞型，第二例为B细胞型。两例均采用睾丸切除术及使用COP-BLAM/IMVP-16方案进行全身化疗，儿童患者还使用甲氨蝶呤预防中枢神经系统受累。治疗反应良好，第一例患者实现完全缓解，目前存活24个月，第二例患者在诊断后5个月因中风死亡，未完成化疗，但肿瘤肿块有显著缩小。本文还对临床、诊断和治疗问题的文献进行了综述。
