Fierro J A, Cuchacovic R, Rodríguez M S, Parra M A, Soto M C
Departamento de Medicina, Facultad de Medicina (Campus Occidente, Universidad de Chile, Hospital San Juan de Dios, Santiago de Chile.
Rev Med Chil. 1995 Jul;123(7):841-8.
We report five patients with vasculitis and antineutrophil cytoplasmic antibodies with cytoplasmatic pattern. All had severe upper and lower respiratory tract necrotizing lesions. Three had kidney failure due to rapidly progressive glomerulonephritis. The pathological study showed a crescentic glomerulonephritis, a chronic granulomatous inflammation in the lungs and in the nasal mucosa, an acute nonspecific inflammation or a chronic granulomatous inflammation and focal blood vessel fibrinoid necrosis. All patients with simultaneous involvement of lungs and kidneys had high titers of antineutrophil cytoplasmic antibodies. The nomenclature and classification of these diseases is discussed.
我们报告了5例患有血管炎且抗中性粒细胞胞浆抗体呈胞浆型的患者。所有患者均有严重的上、下呼吸道坏死性病变。3例因快速进展性肾小球肾炎而出现肾衰竭。病理研究显示为新月体性肾小球肾炎、肺部和鼻黏膜的慢性肉芽肿性炎症、急性非特异性炎症或慢性肉芽肿性炎症以及局灶性血管纤维蛋白样坏死。所有同时累及肺和肾的患者抗中性粒细胞胞浆抗体滴度均较高。文中讨论了这些疾病的命名和分类。
