Ikeda K, Sakurada T, Suzaki Y, Takasaka T
Department of Otolaryngology, Tohoku University School of Medicine, Sendai, Japan.
Rhinology. 1995 Sep;33(3):162-5.
Systemic administration of corticosteroids was attempted in the treatment of olfactory loss resistant to topical corticosteroid treatment in patients with nasal and paranasal disease and post-upper respiratory infection. Significant efficacy was achieved with a short course of high-dose oral corticosteroids in patients with non-allergic sinus disease. On the other hand, anosmia induced by upper respiratory infection failed to respond to systemic corticosteroid treatment, suggesting permanent damage to the olfactory receptor cell. The underlying mechanism of effectiveness observed in patients with sinus disease may be explained by improvement of the mucosal thickening of the olfactory fissure, leading to the access of an odorant to the olfactory neuroepithelium.
对于患有鼻和鼻窦疾病以及上呼吸道感染后对局部用皮质类固醇治疗耐药的嗅觉丧失患者，尝试进行皮质类固醇的全身给药治疗。在非过敏性鼻窦疾病患者中，短期高剂量口服皮质类固醇取得了显著疗效。另一方面，上呼吸道感染引起的嗅觉丧失对全身皮质类固醇治疗无反应，提示嗅觉受体细胞受到永久性损伤。鼻窦疾病患者中观察到的有效性的潜在机制可能是嗅裂黏膜增厚得到改善，从而使气味剂能够接触到嗅觉神经上皮。
