Paşaoğlu H, Kumandaş S, Keleştimur F
Department of Biochemistry, Erciyes University Faculty of Medicine, Kayseri, Turkey.
Turk J Pediatr. 1995 Oct-Dec;37(4):323-9.
Serum osteocalcin levels are a marker of bone formation. In this study, bone and mineral metabolism in type I diabetes mellitus (DM) were investigated, and the changes related to diabetic microvascular complications were examined. Serum calcium (Ca), inorganic phosphate (P), osteocalcin (OC) and parathyroid hormone (PTH) levels were measured in 42 type I diabetic subjects. Diabetics were subdivided into those with or without complications. Age and sex-matched control subjects were used for comparisons with the diabetic groups. Serum P and PTH levels were not different from those of controls. Serum Ca levels were significantly increased (p < 0.001) although the values were within the normal range. OC levels were significantly lower in the complicated (retinopathy and/or protenuria) diabetic group (p < 0.005). In Type I diabetes mellitus, the serum OC level is influenced by the presence of microvascular complications.
血清骨钙素水平是骨形成的一个标志物。在本研究中，对I型糖尿病（DM）患者的骨与矿物质代谢进行了调查，并检测了与糖尿病微血管并发症相关的变化。对42例I型糖尿病患者测定了血清钙（Ca）、无机磷（P）、骨钙素（OC）和甲状旁腺激素（PTH）水平。糖尿病患者被分为有并发症和无并发症两组。选取年龄和性别匹配的对照受试者与糖尿病组进行比较。血清P和PTH水平与对照组无差异。血清Ca水平虽在正常范围内但显著升高（p < 0.001）。在合并（视网膜病变和/或蛋白尿）并发症的糖尿病组中，OC水平显著降低（p < 0.005）。在I型糖尿病中，血清OC水平受微血管并发症的影响。
