Dollfus S, Everitt B, Petit M
Centre Esquirol, CHU Côte de Nacre, Caen, France.
Ann Med Psychol (Paris). 1995 Oct;153(8):517-20; discussion 520-1.
The existence of two subtypes of schizophrenia (positive and negative) is well established. The evidence in favour of other subtypes, in particular a disorganized subtype, is still the subject of some debate. Therefore, the aim of the study was to investigate the possibility of further subtypes of schizophrenia by applying a Ward's method of cluster analysis with the Positive And Negative Syndrome Scale (PANSS) scores in 138 schizophrenic patients. The results from the cluster analysis suggested the existence of at least four sub-types of schizophrenia, positive, negative, mixed and disorganized. Evidence for the validity of these subtypes was provided by the observed differences between the clusters on a number of clinical characteristics. Thus, the negative-positive dichotomy in schizophrenia is an oversimplification, and the existence of a more complex structure needs to be taken into account in future research.
精神分裂症存在两种亚型（阳性和阴性），这一点已得到充分证实。支持其他亚型，特别是紊乱型亚型的证据仍存在一些争议。因此，本研究的目的是通过对138例精神分裂症患者应用基于阳性和阴性症状量表（PANSS）评分的沃德聚类分析法，来探究精神分裂症进一步细分亚型的可能性。聚类分析结果表明，精神分裂症至少存在四种亚型：阳性、阴性、混合型和紊乱型。这些亚型有效性的证据来自各聚类在一些临床特征上观察到的差异。因此，精神分裂症的阴性-阳性二分法过于简单化，未来研究需要考虑存在更复杂结构这一情况。
