Newman E B, Lin R
Biology Department, Concordia University, Montreal, Quebec, Canada.
Annu Rev Microbiol. 1995;49:747-75. doi: 10.1146/annurev.mi.49.100195.003531.
The leucine-responsive regulatory protein (Lrp) regulates transcription of the many genes of the Lrp regulon, repressing some and activating others, some in response to L-leucine and some independent of it. The physiology and molecular biology of the regulon in Escherichia coli are summarized here. However, the high degree of conservation of the protein suggests that it has an important role in all enterobacteria. We suggest that this role is not only as a transcriptional regulator but also as a determinant of chromosome structure.
亮氨酸应答调节蛋白（Lrp）调控Lrp调节子中许多基因的转录，对一些基因起抑制作用，对另一些基因起激活作用，其中一些基因的调控响应L-亮氨酸，而另一些则与之无关。本文总结了大肠杆菌中该调节子的生理学和分子生物学特性。然而，该蛋白的高度保守性表明它在所有肠道细菌中都发挥着重要作用。我们认为，其作用不仅是作为转录调节因子，还作为染色体结构的决定因素。
